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Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy

Received: 31 December 2020     Accepted: 14 January 2021     Published: 22 January 2021
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Abstract

Background: studying hepatocellular carcinoma (HCC) interventional therapy by a simple, noninvasive techniquesthat doesn’t require contrast material is valuable. Doppler ultrasound and fibroscanimaging gives anon-invasive demonstration of blood flow by real time observation and the fibrosis burden which can be related to HCC recurrence. Objectives: The aim of this study was to evaluate the role of fibroscan and Doppler ultrasonography in the assessment of efficacy and safety of hepatocellular carcinoma interventional therapy. Methods: this prospective study was conducted on HCC patients undergoing interventional therapy. The vasculature of both the liver and the focal lesion were assessed using Doppler ultrasonography and liver fibrosis burden was assessed usingfibroscan and compared to CT results. These tests were done one month before and 6 months after intervention. A cut off point of liver stiffness measurement (LSM) at which well ablation can be predicted was evaluated by receiver operating characteristic (ROC) curve. Results: Enrollment of 56 Egyptian patients was done. Portal hypertension (PHT) indices increased significantly after transarterial chemoembolization (TACE) and while did not after microwave ablation (MWA) indicating the safety of MWA. The vascularity of hepatocellular carcinoma point out areas of residual tumor. The TACE group showed high statistically significant increase in LSM after intervention (P<0.001). ROC curve analysis showed that LSM at cut off value ≤ 35.2 KPa can predict good ablation of HCC with a sensitivity 78.38% and specificity 70.83%. Conclusion: TACE is associated with increased portal hypertension indices than MWA and Doppler parameters is a non-invasive simple technique that can be used for follow up of HCC patients after interventional therapy. Also liver stiffness measurement can be used as a good predictor of good ablation of HCC.

Published in International Journal of Medical Imaging (Volume 9, Issue 1)
DOI 10.11648/j.ijmi.20210901.14
Page(s) 36-44
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Hepatocellular Carcinoma, Doppler Ultrasonography, Liver Stiffness Measurement, Portal Hypertention, Fibroscan, Focal Lesion Vascularity

References
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Cite This Article
  • APA Style

    Kariman Elkasrawy, Sabry Abou-saif, Amr El-Badry, Nehad Hawash, Mona Shehata. (2021). Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy. International Journal of Medical Imaging, 9(1), 36-44. https://doi.org/10.11648/j.ijmi.20210901.14

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    ACS Style

    Kariman Elkasrawy; Sabry Abou-saif; Amr El-Badry; Nehad Hawash; Mona Shehata. Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy. Int. J. Med. Imaging 2021, 9(1), 36-44. doi: 10.11648/j.ijmi.20210901.14

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    AMA Style

    Kariman Elkasrawy, Sabry Abou-saif, Amr El-Badry, Nehad Hawash, Mona Shehata. Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy. Int J Med Imaging. 2021;9(1):36-44. doi: 10.11648/j.ijmi.20210901.14

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  • @article{10.11648/j.ijmi.20210901.14,
      author = {Kariman Elkasrawy and Sabry Abou-saif and Amr El-Badry and Nehad Hawash and Mona Shehata},
      title = {Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy},
      journal = {International Journal of Medical Imaging},
      volume = {9},
      number = {1},
      pages = {36-44},
      doi = {10.11648/j.ijmi.20210901.14},
      url = {https://doi.org/10.11648/j.ijmi.20210901.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20210901.14},
      abstract = {Background: studying hepatocellular carcinoma (HCC) interventional therapy by a simple, noninvasive techniquesthat doesn’t require contrast material is valuable. Doppler ultrasound and fibroscanimaging gives anon-invasive demonstration of blood flow by real time observation and the fibrosis burden which can be related to HCC recurrence. Objectives: The aim of this study was to evaluate the role of fibroscan and Doppler ultrasonography in the assessment of efficacy and safety of hepatocellular carcinoma interventional therapy. Methods: this prospective study was conducted on HCC patients undergoing interventional therapy. The vasculature of both the liver and the focal lesion were assessed using Doppler ultrasonography and liver fibrosis burden was assessed usingfibroscan and compared to CT results. These tests were done one month before and 6 months after intervention. A cut off point of liver stiffness measurement (LSM) at which well ablation can be predicted was evaluated by receiver operating characteristic (ROC) curve. Results: Enrollment of 56 Egyptian patients was done. Portal hypertension (PHT) indices increased significantly after transarterial chemoembolization (TACE) and while did not after microwave ablation (MWA) indicating the safety of MWA. The vascularity of hepatocellular carcinoma point out areas of residual tumor. The TACE group showed high statistically significant increase in LSM after intervention (P<0.001). ROC curve analysis showed that LSM at cut off value ≤ 35.2 KPa can predict good ablation of HCC with a sensitivity 78.38% and specificity 70.83%. Conclusion: TACE is associated with increased portal hypertension indices than MWA and Doppler parameters is a non-invasive simple technique that can be used for follow up of HCC patients after interventional therapy. Also liver stiffness measurement can be used as a good predictor of good ablation of HCC.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Fibroscan and Doppler Ultrasonography in the Assessment of Hepatocellular Carcinoma Interventional Therapy
    AU  - Kariman Elkasrawy
    AU  - Sabry Abou-saif
    AU  - Amr El-Badry
    AU  - Nehad Hawash
    AU  - Mona Shehata
    Y1  - 2021/01/22
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijmi.20210901.14
    DO  - 10.11648/j.ijmi.20210901.14
    T2  - International Journal of Medical Imaging
    JF  - International Journal of Medical Imaging
    JO  - International Journal of Medical Imaging
    SP  - 36
    EP  - 44
    PB  - Science Publishing Group
    SN  - 2330-832X
    UR  - https://doi.org/10.11648/j.ijmi.20210901.14
    AB  - Background: studying hepatocellular carcinoma (HCC) interventional therapy by a simple, noninvasive techniquesthat doesn’t require contrast material is valuable. Doppler ultrasound and fibroscanimaging gives anon-invasive demonstration of blood flow by real time observation and the fibrosis burden which can be related to HCC recurrence. Objectives: The aim of this study was to evaluate the role of fibroscan and Doppler ultrasonography in the assessment of efficacy and safety of hepatocellular carcinoma interventional therapy. Methods: this prospective study was conducted on HCC patients undergoing interventional therapy. The vasculature of both the liver and the focal lesion were assessed using Doppler ultrasonography and liver fibrosis burden was assessed usingfibroscan and compared to CT results. These tests were done one month before and 6 months after intervention. A cut off point of liver stiffness measurement (LSM) at which well ablation can be predicted was evaluated by receiver operating characteristic (ROC) curve. Results: Enrollment of 56 Egyptian patients was done. Portal hypertension (PHT) indices increased significantly after transarterial chemoembolization (TACE) and while did not after microwave ablation (MWA) indicating the safety of MWA. The vascularity of hepatocellular carcinoma point out areas of residual tumor. The TACE group showed high statistically significant increase in LSM after intervention (P<0.001). ROC curve analysis showed that LSM at cut off value ≤ 35.2 KPa can predict good ablation of HCC with a sensitivity 78.38% and specificity 70.83%. Conclusion: TACE is associated with increased portal hypertension indices than MWA and Doppler parameters is a non-invasive simple technique that can be used for follow up of HCC patients after interventional therapy. Also liver stiffness measurement can be used as a good predictor of good ablation of HCC.
    VL  - 9
    IS  - 1
    ER  - 

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Author Information
  • Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Radiodiagnosis Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt

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